pentobarbital will lower the level or effect of theophylline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will lower the level or impact of pimozide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unfamiliar.
Minimal (one)pentobarbital will decrease the level or outcome of paclitaxel protein certain by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unidentified.
Warning is warranted for individuals with renal and hepatic impairment. When the maker does not offer precise dosage adjustment suggestions for renal impairment, checking kidney purpose when administering high doses or conducting extended therapy is important.
Barbiturates could potentially cause fetal harm when administered to some Expecting female; retrospective, case-controlled experiments have recommended a link among maternal intake of barbiturates and an increased-than-envisioned incidence of fetal abnormalities
Keep an eye on Closely (two)pentobarbital will lower the level or effect of oliceridine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. If coadministration having a CYP3A4 inducer is essential, consider expanding oliceridine dose until get more info eventually stable drug outcomes are accomplished; keep track of for signs of opioid withdrawal.
pentobarbital will lessen the extent or influence of estropipate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital will minimize the level or impact of sunitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital increases toxicity of buprenorphine, long-performing injection by pharmacodynamic synergism. Modify Therapy/Observe Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants boosts risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is most popular generally.
Caution when discontinuing CYP3A4 inducers which might be coadministered with hydrocodone; plasma concentrations of hydrocodone may boost and may lead to potentially deadly respiratory despair
pentobarbital will lower the level or impact of fedratinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Impact of coadministering a powerful CYP3A4 inducer with fedratinib has not been researched.
pentobarbital will lessen the level or outcome of cinacalcet by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
Keep an eye on Carefully (1)pentobarbital will lower the level or impact of gefitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Contraindicated (1)pentobarbital will decrease the extent or influence of lumacaftor/ivacaftor by impacting hepatic/intestinal enzyme CYP3A4 metabolism.